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10.1016/j.jinorgbio.2015.09.003 58 SteinbrennerH.SiesH

Future studies on the role of oxidative stress in the comorbidity of both diseases should further clarify the nature of these processes, identify common mechanisms involved in the course of diseases, and consider the role of antioxidants in the development of therapeutic strategies

In cardiometabolic contexts such as DM2 and HTN, agents like SGLT2 inhibitors and AMPK/Sirtuin modulators illustrate how metabolic correction can dovetail with oxidative protection

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Methods Sixteen weeks old nulligravid female Wistar rats were housed at a constant temperature (22C) in a 12 hours light and dark cycle environment with free access to food and drinking water