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AD patients often exhibit lower ejection fractions, lower cerebral blood flow velocities, and greater vascular resistance

Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

F.CarcilloJ

Loss of barrier integrity facilitates translocation of luminal bacteria, endotoxins, dietary antigens, and metabolic waste into the systemic circulation, activating maladaptive immune responses that drive mucosal inflammation

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