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Tolerance refers to the reduction in or loss of drug efficacy caused by long-term administration and indicated by the pharmacological changes to the right of the dose-response curve, the development and degree of which depend on the drug interactions with the opioid receptors, drug dose, and frequency of administration [15]

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GSH augmentation deserves investigation as a beneficial therapeutic approach for not only PD but also numerous other CNS disorders for which GSH deficiency and GSH-related enzyme deficits have been documented (multiple sclerosis, 25,26 autism, 2729 Alzheimers disease, 30,31 schizophrenia, 32,33 and bipolar disease 34 )

Hepatology 2020;71:306-333

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