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Trujillo-Mayol, I., M

However, UCLA Health reports that the broader at-risk population those with suboptimal or marginally low levels may reach up to 20% of adults over 60 (2022)

Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula is far below such neurotoxic levels

(Boachie J, et al., Nutrients, 2020 PubMed: 32630646 ) Inositol and metabolic benefit A 2024 meta-analysis in the Journal of Clinical Endocrinology and Metabolism found inositol produced selective metabolic benefits in women with PCOS primarily as oral supplementation, not injected MIC formulas