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Lonskaya, I., Desforges, N

The studies reported thus far have used exhaustion models of endurance-based exercise leaving the area of resistance exercise, specifically damaging eccentric exercise a major area of research to be conducted

Traditional Chinese herbal extracts, such as artemisinin, also interfere with iron metabolism, increase Fe 2+ concentration, and induce ferroptosis (Han et al., 2020)

The specific mechanisms remain under investigation, but the finding adds another dimension to DSIP's systemic regulatory effects

It enables large endogenous neuropeptides, enzymes, growth factors, transferrin and hormones, among the others, to penetrate the BBB harnessing their specific receptors that are highly expressed on the luminal side of endothelial as widely discussed in (Saraiva et al., 2016) and further explained, with representative examples, in section Preclinical achievements of polymeric nanoparticles-mediated drug delivery in Alzheimers disease. The same strategy can also be exploited to deliver drugs against AD into the brain, using surface-modified polymeric NPs as further described in section Polymer functionalization strategies, or even circulating exosomes (Wang et al., 2019)