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Modern industrial toxins include heavy metals (such as lead, iron, manganese, and selenium) and pesticides (such as organochlorines, pyrethoids, herbicides, and fumigants) [58]

Cell Mol Life Sci (2022) 79(5):228

Visible light, particularly within the blue spectrum, has been shown to induce higher-order chromatin and chromatid damage, including chromatin condensation, chromatid breaks, sister chromatid exchanges (SCEs), and micronucleation 138,142,171,178,182,186,187,188

The top 3 negatively enriched HALLMARK terms in high IGF-1 subgroups were epithelial mesenchymal transition, KRAS upsignaling, and allograft rejection ( Figure 8C ), and the top positively enriched HALLMARK terms were MYC targets V2, reactive oxygen species pathway, oxidative phosphorylation, and DNA repair ( Figure 8D )