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Furthermore, QFPDD suppressed the activation of M1 macrophages and reduced the levels of IL-6, TNF-, MIP-2, MCP-1, and IP-10 while increasing IL-10 expression, as reported by Ye et al

[28] The mechanism of action of cyclobenzaprine as a muscle relaxant is unknown

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Indeed, significant gene-level methylation changes have been consistently reported in various cohorts