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Further details relating to IgE regulation of mast cell survival can be found in several reviews (Kawakami and Galli, Effects on mast cell activation Both publications discussed in the previous section show the results of additional assays of IgE stimulation of cytokine and leukotriene synthesis and secretion and cell degranulation (Asai et al., in vivo situation, they pointed out that the cytokines would also act on cell populations other than mast cells to enhance allergic (or cytokinergic) inflammation by, for example, inducing B cells to make more IgE by a positive feedback mechanism (Figure 2)