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The translocation and activation of NF-B in response to various stimuli, such as cytokines (IL-1 and TNF-), microbial agents (lipopolysaccharide-endotoxin), oxidative challenge (ROS) and irradiation (UV and -rays), are sequentially organized at the molecular level [54, 55, 104]

The hydrolysis can be carried out using typical processes, for example, acidic or enzymatic catalyzed processes

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Instead, the effects are often subtle and cumulative

Ethics statement The animal study was approved by Research Ethics Committee (REC) at King Saud University (approval number KSU-SE-25-28)