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Over the past decades, a variety of downstream effector pathways and their connectivity have been elucidated [8], and it has been suggested that the conformational plasticity of GPCRs [9] and GPCR-transducer complexes also contribute to biased signaling and complexities of GPCR signaling [10, 11]

After vortexing, the samples were centrifuged at 13,000 RPM for 20 min at 4 C

The signal-to-noise ratio (SNR) was obtained using a N-acetylaspartate (NAA) peak height of 2.01 ppm divided by the standard deviation (S.D.) of noise

In: Fu, H

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