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In monotherapy, intraperitoneal HCQ significantly decreases tumor growth in LUAD xenograft nude mice via the STAT3FoxO3ap27 Kip1 signaling pathway [115]

doi: 10.1186/s11671-024-03985-y 113 SiYZhangYNgoHGGuanJ-SChenKWangQet al

The mechanism formally parallels the -elimination reaction catalyzed by PLP-dependant enzymes which accept cysteine thioethers as substrates and likely play a role in the renal toxicity and carcinogenicity of halogen-alkenes through their urinary metabolites [125]