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Experiments by Avery and his colleagues in 1944 provided definitive proof that DNA is the genetic information with its transforming ability in bacteria (Watson and Crick, 1953), and its double-helical structure with base-pairing according to Chargaffs rules ( The involvement of messenger RNA (mRNA) in the central dogma was floated since 1947 but the experimental discovery came in the year 1961 by Francois Gros and Francois Jacob (Jacob and Monod, 1961)

Use of APAP in babies and small children was not monitored as medical practice changed To establish any association between the use of APAP in the pediatric population and the incidence of neurodevelopmental disorders, it is most convenient to establish the prevalence of both factors over time with some degree of certainty

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