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Changes in the subpopulation Analysis of the cellular distribution of peripheral blood cells revealed no significant differences in the proportions of classical (CD14 + CD16 ), intermediate (CD14 + CD16 + ), and nonclassical (CD14 CD16 + ) monocyte subpopulations between PD patients and controls [23]

Substantial heterogeneity observed between these subgroups underscores the need for future studies to standardize stimulation protocols and cognitive assessment criteria to improve evidence reliability