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Patients with ACOX1 (p.N237S) exhibit loss of glia, Schwann cells and neurons

Glial cell-derived neurotrophic factor induces enteric neurogenesis and improves colon structure and function in mouse models of Hirschsprung disease

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doi: 10.2527/2000.7841078x 84 MtayerS.SeiliezI.CollinA.DuchneS.MercierY.GeraertP

Class I (e.g., erastin, sulfasalazine (SAS)) targets xCT and cystine uptake [19, 23, 24], Class II (e.g., RSL3, ML162) targets GPX4 enzymatic activity [25], Class III (e.g., FIN56) depletes GPX4 and ubiquinone [26], and Class IV (e.g., FINO2) indirectly inhibits GPX4 while directly oxidizing iron [27,28,29]