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Furthermore, allosteric modulation of 7 nAChR with AVL-3288 alleviated social approach deficits and repetitive grooming behaviors in a BTBR mouse model [56]

In a study that included 321 female volunteers with and without signs of PCOS, higher morning melatonin levels were associated with expression of a higher number of PCOS-related features (hyperandrogenism, few or no periods, and cystic ovaries), suggesting PCOS may be associated with disrupted circadian signaling