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Possible reasons include the Washington State University patent holders not finding a pharmaceutical company willing to invest in development, the cancer biology concern with c-Met activation making development companies cautious, the preclinical effect sizes in rats not justifying the expense and risk of human trials, or other factors specific to drug development economics

Reduced melanin implies lighter, brighter, and more evenly toned skin

In the Phase 2 trial, participants on the 12 mg dose were still on a steep weight loss trajectory at 48 weeks, losing roughly 5-6 pounds per month even late in the treatment period

[31] The New York Times wrote that she garnered popularity with "her ability to rattle off one-liners"