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Frequency of Metformin-Associated B12 Deficiency An association between metformin therapy and B12 deficiency was first reported in 1969

First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies

Anaemia-related fatigue adds another layer, because a fatigued patient moves less after surgery, and immobility is itself a clotting risk

Without enough, you might feel numb, have trouble balancing, or struggle with thinking clearly

It is best to consult with a healthcare professional who can assess your specific situation and provide personalized recommendations