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This allows the thiolate anion to access the hydrophobic binding site exposed to the membrane, thereby aiding in the reduction of membrane-bound phospholipid hydroperoxides and the conjugation of additional hydrophobic electrophiles

112 ShuQKangCLiJHouZXiongMWangXet al

Dolgikh D

Two more GPX4-independent systems that prevent lipid peroxidation and ferroptosis are reported in 2020 and 2021

Stimulation of microglia with LPS has been shown to induce the expression of several genes that are regulated by mitogen-activated protein kinases (MAPKs) and NF-B, including such cytokines as TNF-, interleukin (IL)-1b, interferon (IFN)-, and their receptors, as well as the stress proteins superoxide dismutase (SOD) 2, COX-2, and thioredoxin interacting protein [62,63]