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In these more serious cases, an abdominal ultrasound study may reveal findings consistent with small intestinal disease, although thickened intestines or enlarged abdominal lymph nodes can be non-specific (Figure 5)

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The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [3336]

Kiyotani T, Teramachi M, Takimoto Y, et al

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