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ROS accumulation triggers the dissociation of Nrf2 from its cytoplasmic inhibitor Keap1, facilitating Nrf2 nuclear translocation

A proof-of-concept phase 2 study compared two doses (50 and 150 mg) of this first-in-class drug to placebo in PD patients on dopaminergic treatment with an OFF-time of at least 2 h [152]

Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages

then, I-b can bind to NF-B to inhibit its activation and, thus, reduce NSAID-induced intestinal injury (Watanabe et al., 2009)