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Chronic Inflammatory Bowel Disease (IBD) Inflammation of the ileum and disruption of the gut barrier can significantly reduce B12 absorption

By improving the bodys insulin use, it may help regulate blood sugar levels

[3] A common repletion strategy in profoundly deficient adults involves 100,000 IU intramuscularly every four weeks for two or three doses or a one-off 300,000 IU injection followed by oral maintenance