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Collectively, mitochondria as the primary generators and the recipients of oxidative damage, implies a vicious cycle wherein impaired mitochondria produce increased amounts of ROS, in turn leading to a progressive accumulation of damage that culminates in the process of aging (Figure 1)

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revealed that implanted 3D-printed Alg-Bi2S3@BSA (containing bismuth nanoparticles) under tumor tissue in a murine model by reducing the tumor volume growth rate under single-dose X-irradiation shows high therapeutic efficacy 38

doi: 10.1074/jbc.M412694200