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Results Association of peptide proteoforms with age, sex and post-mortem interval Nontryptic mass spectrometry was performed on 102 human cortical samples obtained post-mortem from the angular gyri of individuals stratified into four diagnostic classes: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)

All findings referenced are from peer-reviewed preclinical studies