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(90) confirmed that patients with obesity, NAFLD, and diabetes all exhibit significantly increased intestinal permeability, with mechanisms involving increased intestinal pathogenic bacteria and inhibitory effects of hyperglycemia and hyperlipidemia on tight junction protein expression

Whereas non-cystic fibrosis cells upregulate CHAC1 following infection with various pathogens (including Pseudomonas aeruginosa , human coronavirus, cytomegalovirus, tick-borne flaviviruses, Zika virus, and Mycoplasma hominis ), cystic fibrosis cells show an impaired response

Alternatively, studies using tau-driven AD models of worms and mice explored the effects of NMN treatment

10.1016/j.jnutbio.2014.07.003 81 KontoghiorghesG

10.1016/bs.enz.2024.06.005 31 FengG.WuJ.YangH