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1 (download XLSX Statistical source data of Extended Data Fig

Key data: Published studies show improved glucose metabolism and exercise performance markers For current clinical trial data, see our MOTS-c clinical trials status 2026 breakdown

These long haulers commonly experience one or more of the following symptoms, some of which can be debilitating: A pins-and-needles sensation Changes in period cycles Chest or stomach pain Cough Diarrhea Difficulty breathing or shortness of breath Difficulty thinking or concentrating (sometimes referred to as brain fog ) Dizziness upon standing (lightheadedness) Fever Headache Heart palpitations (heart beating fast or pounding) Joint or muscle pain Lost or diminished sense of smell or taste Mood changes Rash Sleep problems Symptoms that get worse after physical or mental activities Tiredness or fatigue Officially, COVID-19 long haulers are said to suffer from PASC, which is short for post-acute sequelae of SARS-CoV-2

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10.3389/fphar.2021.632388 103 LiQ.ZhangY.YangY.HuangS.ZouX.WeiC.et al (2021c)