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Another intriguing option to affect the microbiota is to change the level of oxygen in the GI lumen using its chemical donors (XEN-101)

Compliance Both arms had similarly high compliance to the study treatment, with the average compliance across all 6 months being 95.4% and 95.7% in the intervention and placebo arms, respectively

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In addition, it can also be offered to those patients who do not have satisfactory intercourse, present failure in conservative treatment and those seeking quicker results 6

P = 0.09), though heterogeneity between studies was moderate (I =50%)