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Treatment of rats with benfotiamine, a synthetic analogue of thiamine (vitamin B1) and an inhibitor of hexosamine pathway and formation of advanced glycation end products, has been shown to improve DPN (62)

European journal of nutrition, 55(1), 207-217

An enzyme called glutathione peroxidase then sparks the conversion of reduced glutathione to oxidized glutathione, a free radical itself

2019;8doi:10.12688/f1000research.18901.1 Ketelhuth DFJ, Lutgens E, Bck M, et al

The oxidative stress injury involves the initiation and progression of inflammatory cascades, which consequently elevate the levels of inflammatory cytokines