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APOE4 Carriers: Little evidence exists on how carnitine treatment affects APOE4 positive or negative patients

The enzyme carnitine acetyltransferase (CrAT), which produces acetylcarnitine from carnitine and acetyl-CoA, plays a critical role in combating glucose intolerance and maintaining metabolic flexibility

This data indicates that microbiota indeed contributes to changes in BCAA plasma levels, in which altered gut microbiota could be another underlying cause of elevated BCAA levels in individuals with insulin resistance