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W., Cirilli M., Lin C., Xu H

Everything else is secondary to that

Vaccinia-related kinase 2 drives pancreatic cancer progression by protecting Plk1 from Chfr-mediated degradation

For example, HIF1- and HIF2-dependent transcriptional programmes have been linked to metastatic progression in several tumour types, 123,124,125,126 suggesting that activation of the hypoxia response in primary tumours might be important for metastatic tumour growth in the secondary organs