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10.1016/j.apsb.2023.01.018 Summary Keywords phytochemical nanosystems, cancer nanotherapy, tumor microenvironment, gene modulation, microfluidics, microphysiological systems, translational nanomedicine, SDG 3 Citation Peaherrera-Pazmio AB, Criollo M and Gonzalez-Pastor R (2025) Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation

While NAC demonstrated promising clinical and mechanistic effects at moderate dosing regimens, evidence from higher-dose administration raises important safety considerations

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For example, breast cancer cell lines had a high capacity to reach the oxidized form of VIC due to overexpression of SVCT2 genes, associated also with a higher resistance to oxidative stress