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The Western blot method referred to our previous study 49

Damage to the mitochondrion that results in release of cytochrome c can stimulate assembly of the apoptosome and activation of the caspase cascade that leads to programmed cell death

This requires moving beyond the standard hypothyroidism playbook into an autoimmune-specific strategy

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417 Oxidized mtDNA is released into the cytosol via mPTP and VDAC-dependent channels on mitochondria, activating the NLRP3 inflammasome and driving a range of inflammatory diseases