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Parkin (i.e., Park2) is an E3 ubiquitin ligase that is believed to play an important role in directing misfolded proteins for degradation via the ubiquitin-protease system 74 and helps regulate mitochondrial dynamics through mitochondrial biogenesis, import of mitochondrial proteins and mitophagy (targeting mitochondria to phagosomes) 75

While water kefir constitutes an essential source of probiotics and prebiotics, especially for vegansor people with milk allergy/intolerance, milk kefir, which has similar probiotic and prebiotic content, also contains high protein (105)

Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice

T.YuhE.et al (2019)

doi: 10.1097/SHK.0b013e3181ec71ab 67