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Although metabolomics has improved the understanding of the pathogenesis of RA, some studies have reported inconsistent results (6466)

The treatment usually takes 24 weeks depending on the response

When evaluating the quality of the 18 articles 2 , 6 , 11 - 26 selected through the Jadad Scale, their scores ranged between 2 and 5, with a median score of 5 (Table 1)

The use of clinical data was approved by the Institutional Review Board of the Faculty of Medicine Siriraj Hospital, Mahidol University (Si191/2560)

The transcription factor NF-B is an important regulator of immune and inflammatory responses, and NF-B p65-mediated increased trans-activation plays a key role in the pathogenesis of chronic inflammatory diseases (210)