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Studies show that folic acid supplementation reduced odds of chronic kidney disease progression in patients with CKD, but only in those with adequate B12 levels, highlighting how these nutrients need each other to work properly

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Neurological symptoms such as numbness or tingling in the hands and feet, balance issues, and memory problems may also occur

Shared Risk Factors Research consistently points to a handful of contributors: Family history of mood disorders, which raises risk for both conditions Trauma , especially in childhood, which is strongly linked to chronic depression in particular Chronic stress at work, in caregiving, or in financial or social conditions Substance use , which can precipitate, deepen, or mimic depression Medical conditions like hypothyroidism, chronic pain, and other systemic illnesses How Are MDD and PDD Diagnosed