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Additionally, we explore the beneficial and damaging consequences of reactive astrogliosis in dopaminergic neurons during PD, particularly on oxidative damage, which is a main component of numerous neuropathological conditions, and that may have a damaging effect in astrocytic functions

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For those on longer-acting opioids like methadone or the partial agonist buprenorphine, the withdrawal symptoms probably wont be as intense, but the timeline will be significantly extended

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Tirzepatide is a dual-agonist (GLP-1 + GIP)