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Similarly, Lipid nanoparticles (LNPs) carrying indinavir (IDV) achieved higher lymph node drug levels, increased intracellular PBMC concentrations, prolonged plasma residence, restored CD4 T cells, and suppressed viral RNA in primates

Additional experiments demonstrated that HO-1 induction was dependent on the TrxR redox activity since restoring intracellular levels of reduced Trx was sufficient to increase HO-1 expression when endothelial cells were cultured in Se-deficient media (less than 01 ppm Se) ( Reference Trigona, Mullarky and Cao 36 )

This was first explored by Balthasar and colleagues, who in 2005 proved that specific inhibition of the IgG:FcRn interaction by use of a murine mAb (mouse IgG1, clone 4C9) with V regions specific for rat 2m generated by Bjorkman and colleagues could deplete endogenous IgG levels in rats [113, 114]

Bartos M, Vida I, Jonas P