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Currently, the mainstream therapeutic armamentarium for IBD encompasses conventional agents (5-aminosalicylates, corticosteroids, and traditional immunosuppressants such as azathioprine), biologics, and small-molecule inhibitors, all of which have demonstrated efficacy in inducing and maintaining remission and in ameliorating symptomatic burden

Ser/gly synthesis dependence led to an enhanced synthesis of nucleotides in 2012.2 GBM cells, as well as in 1919 GBM isogenic models with overexpression of PSPH and the PSPH V116I mutation, which explains their high sensitivity to the inhibitory effects of sertraline plus chloroquine treatment