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HA-iMSC-EVs displayed characteristic features of extracellular vesicles and exhibited superior effects relative to iMSC-EVs, including enhanced angiogenesis, improved endothelial cell survival under oxidative stress, decreased reactive oxygen species generation in cardiomyocytes, heightened anti-inflammatory activity in macrophages, and inhibition of fibrosis-related signaling

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A total of 39 RCTs involving 1714 participants were included

Given that praziquantel is the only effective treatment for schistosomiasis, there is an increasing concern that drug resistance may become more prevalent (Utzinger et al., 2009