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doi: 10.3389/fcvm.2025.1638747 Received 31 May 2025 Accepted 29 July 2025 Published 12 August 2025 Volume 12 - 2025 Edited by Alicia Del Saz Lara, University of Castilla-La Mancha, Spain Reviewed by Binaya Basyal, MedStar Washington Hospital Center, United States Taner Ulus, Eskiehir Osmangazi University, Trkiye Updates Copyright 2025 Deng, Li, Li, Li, Cheng and Xiao

270 Moreover, H 2 O 2 was also shown to mediate NF-kB activation in an IKK-dependent way by regulating the PI3K/PTEN/AKT signaling cascade

This may potentially be achieved by activating the adenylate cyclase, which may convert ATP to cAMP

However, its inhibition reduces tumor invasion, GSCs self-renewal, and progression, reinforcing its therapeutic potential

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