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These were all 5-HT1b agonists characterized for their ability to inhibit food consumption, but also had effects on other serotonin receptors that lead to unacceptable side effects (cardiac valvular thickening) and were voluntarily withdrawn from the market

How This Works Tirzepatide is a dual GLP-1/GIP receptor agonist : it activates both the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) incretin receptors, which together regulate appetite, glucose-dependent insulin release and glucagon [1] [5]

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In addition to helping people lose weight, clinical research has shown that the AOD-9604 peptide can support joint health and cartilage repair, which may help people with osteoarthritis or other joint ailments