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However, in the evaluation of adverse reactions, the incidence of neutropenia in Japanese patients was higher than that in Western patients (76, 77) Thus, a randomized, multicentre, double-blind phase 3 RAINBOW-Asia trial (78, 79) (a bridging study similar to RAINBOW) was initiated, in which patients were randomized to receive ramucirumab plus paclitaxel (n=294) or placebo plus paclitaxel (n=146), the primary outcome was (mPFS 4.14 months vs 3.15 months, mOS 8.71 months vs 7.92 months), and the most common adverse reaction was also decreased neutrophil count (54% vs 39%)

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(41) have recently discussed the relationships of these proteins and suggested that they should be classified into two types, which they termed farinins and purinins

No statistically significant pCR differences were noticed between the groups, however, the subgroup analysis showed that for HR+ patients under 40 years old, combination therapy with paclitaxel + olaparib can lead to higher pCR rates

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