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The nitric oxide produced plays a vital role in regulating cell physiological functions and metabolic processes, including blood pressure regulation, immune response, and apoptosis, by modulating cell signaling pathways (Kokai et al., 2022

Although fatigue and fatigability essentially result from a central phenomenon (since MS is a disease of the central nervous system), there are some central al peripheral factors to take into consideration when exploring the phenomenology of fatigue

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B-complex vitamins include vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B7 (biotin), vitamin B9 (folate), and vitamin B12 (cobalamin)

Front Neurosci 14:579953