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In the ScWAT, a positive correlation was observed between serum B12 levels and FAO genes (MCD, CPT1, ECHS1, CPT2, ACADL, ACAA2, Fig

As for the initial oxidation step ( i.e., Reaction 2), the favored species are the thiolate (nucleophile) and the protonated RSOH (electrophile), and hence, a bell-shaped pH dependency is expected for this reaction too