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Cardiovasc Res 67:225233 Botti H, Trostchansky A, Batthyany C, Rubbo H (2005) Reactivity of peroxynitrite and nitric oxide with LDL

In the following sections, we summarize some of the most important aspects of mGSH physiology, its role in mitochondrial function and release of mitochondrial apoptotic factors and the impact of its depletion in disease

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Consistently, GSH depletion or silencing of Fe-S cluster-associated GLRXs disrupts mitochondrial redox balance, promotes iron overload, and sensitizes cancer cells to ferroptosis 133,134

doi: 10.1016/j.biteb.2025.102154 49