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HSP70 proteins are necessary for cell repair and survival under stressful conditions, their amount correlates with the severity of various pathological conditions, such as ischemia, inflammation, autoimmune processes, malignant tumors, bacterial and viral infections, and neurodegenerative diseases (Ortan et al., 2018

Functionally, lactylation orchestrates a multifaceted regulatory network spanning, including transcriptional activation, protein stability, enzyme activity, proteinprotein interactions, protein subcellular translocation, and crosstalk with other PTMs

Identification of 6 cuproptosis-related genes for active ulcerative colitis with both diagnostic and therapeutic values

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All structural figures were generated using UCSF Chimera 99 , Chimera X 103 , and PyMOL (Schrdinger, LLC, Homology modeling of outward-facing ABCB7 The outward-facing conformation of human ABCB7 was modeled using the structure of human ABCB6 in the outward-open state (PDB ID 8K7C) as reference template 57