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318 The real-time in vivo bone-sensing smart biomaterials can dynamically adjust treatment protocols based on the actual status of bone tissue, enhance therapeutic outcomes and promotes the swift recovery of bone tissue

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N Engl J Med 341 : 785792 Clemmons DR (1993) Use of growth hormone and insulin-like growth factor I in catabolism that is induced by negative energy balance

Several studies (Table 3) have shown that LA significantly reduces body fat mass, hepatic clearance of TG-rich lipoproteins, and lipid droplets through upregulating the expression levels of hepatic lipolytic enzymes (ATGL, acyl-CoA thioesterase [Acot1], Acot2, Acsf2, and Crat) and downregulating the expression levels of liver lipogenic enzymes (patatin-like phospholipase domain protein [Pnpla3], Pnpla5, Elovl6, Acly, sn-glycerol-3-phosphate acyltransferase 1 [Gpat], Aacs, FASN, ACC, and SCD-1)

Studies indicate the peptide may help restore normal sleep-wake cycles disrupted by stress, creating a positive feedback loop where improved sleep further enhances stress coping capacity