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2.Glutathion synthesis The first step of GSH synthesis is rate-limiting and catalyzed by glutamate-cysteine ligase (GCL) formerly referred to as -glutamylcysteine synthetase (GCS)

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Instead, it is essential to conduct in-depth analyses of the specific logic of the aforementioned signaling networks in terms of cell types, subcellular compartments, and disease course timings, and clarify their context-dependent controversies to promote the transformation of mechanistic understanding into precision treatment

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Mechanisms of RBC maturation and senescence RBCs life cycle is defined by strictly regulated processes of maturation and senescence, ensuring that RBCs efficiently perform their oxygen transport function throughout their lifespan