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Mechanistically, ROS generated by pyocyanin triggers the release of pro-inflammatory cytokines such as the neutrophil chemotactic factor IL-8 in a NF-B-dependent manner through the MAPK/ERK signaling (98, 99), further contributing to the pathological effects observed during P

In addition, especially during prophase I of meiosis, spermatogonia carrying pathogenic mtDNA may accumulate large amounts of mutant mtDNA in spermatocytes, while maintaining normal mitosis, inducing mitochondrial respiratory dysfunction and decreasing OXPHOS activity [122]

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Song A., Zhu X., Chen F., Gao H., Jiang J., Chen S