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This effect can last for several minutes and is believed to be driven by an accumulation of calcium ions in the presynaptic terminal

[3] Another review of 14 randomized controlled trials also did not consistent evidence of benefit with the use of vitamin B12 supplements, alone or with other B vitamin supplements, on cognitive function in people with either normal or impaired cognition

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Kaeser PS, Regehr WG (2017): The readily releasable pool of synaptic vesicles