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In the case of CBS, the function of the AdoMet-binding regulatory domain appeared less important than the catalytic domain to functional complementation, as variants in this domain were generally more likely to be tolerated in our assay

Abnormal insula activity has been found in ME/CFS, fibromyalgia and other co-morbid disorders and one study has found evidence that increased awareness of the heartbeat is present in ME/CFS

These enzymes are deemed essential for neutralizing harmful free radicals and maintaining cellular integrity

Genome-wide identification, characterization, and expression analysis related to autotoxicity of the GST gene family in Cucumis melo L